The cytologic reaction of the spleen in experimental amyloidosis in mice.

MYLOIDOSIS has been experimentally produced in mice by repeated injections of sodium caseinate,’ of Freund’s adjuvant,2 and of Freund’s adjuvant plus brain.3 Teilum produced the condition in rabbits by hyperimmunization with Pfeiffer’s bacillus. In the spleens of the animals he found a marked proliferation of plasma cells, many of which stained positively with periodic acid-Schiff ( PAS ) . Since there has been little detailed comment on the cytology of the spleen in animal anlyioidosis, it was thought that further study of this aspect might ilelp clarify the illtricate mechanism underlying the production of amyloid. \Vith this aim in view, the reactions of nli(’e to the injection of both weak and strong antigens were investigated.